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Retatrutide is an injectable triple agonist that targets GIP (glucose-dependent insulinotropic polypeptide), GLP-1, and glucagon receptors (GCG receptors) simultaneously
The nausea and appetite suppression it causes follow directly from the locations of those receptors (Wilding et al., NEJM 2021)
Meanwhile, Ozempic primarily targets GLP-1 alone
The ubiquinone form is in an oxidized state, which means it's an electron acceptor
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