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Overall, 9095% of serum DPP-4 activity is related to soluble DPP-4 levels [27,28,29,30,31]

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Clinical data confirm that both options are truly effective

5 KEY APPROACHES TO OVERCOME CHALLENGES IN PEPTIDE DELIVERY Protein engineering to resist enzymatic degradation Enzyme inhibitors and stabilizers for protection and stability PEGylation and albumin binding for half-life extension Enteric coatings for pH protection Encapsulation systems (eg, nanoparticles, liposomes) Permeation enhancers like SNAC Mucoadhesive systems for prolonged mucosal contact Several of these approaches are achieved by use of appropriate excipients

Working with the students is especially rewarding