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The consequences of these conditions extend far beyond the endocrine system, with neurological and psychiatric effects emerging as critical yet under-recognized dimensions of the disease burden

Acknowledgements This research was supported in part from generous contributions from GoodLifes Childrens Foundation and Autism Research Institute to DFM

FIGURE 7 High-performance liquid chromatography analysis showed that BSO treatment led to a 94 and 96% reduction in GSH and hGSH content, respectively, in wild-type roots with nodules (Supplementary Table 4)

To overcome the barriers and to improve the adherence, oral GLP-1 RAs were needed, but oral protein-based drug absorption is limited because of degradation in the stomach due to low pH, proteolytic enzyme activity, and limited permeability across the gastrointestinal (GI) epithelium

Treatment will focus on symptom management and preventing complications, like secondary infections