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Avoid hot drinks until temperature perception normalizes

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Participants who took 2.4 mg of semaglutide weekly lost an average of 14.9% of their body weight over 68 weeks (about 16 months), compared to 2.4% in the placebo group

3% to 5%: These concentrations are often found in stronger treatments used for addressing more severe pigmentation issues like melasma and stubborn dark spots

Mechanistic reviews by Chelakkot et al., published in Experimental & Molecular Medicine (2018) , describe how dysregulation of these junctions is associated with increased intestinal permeability and immune activation