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Insurance Coverage Predictions CagriSema (Advantage: Semaglutide Component): Leverages Wegovy's established coverage "Combination of proven medication + new molecule" easier sell to insurers Predicted coverage: 50-60% of commercial plans initially Retatrutide (Challenge: Novel Molecule): Entirely new drug class, no established coverage Higher efficacy but also higher side effects Will likely require trial-and-failure of cheaper options Predicted coverage: 40-50% of commercial plans initially Clinical Trial Populations and Indications CagriSema: Diabetes Focus REDEFINE-1: Obesity without diabetes (3,417 participants) REDEFINE-2: Obesity WITH type 2 diabetes (1,206 participants) REIMAGINE Program: Additional diabetes-focused trials Advantage: Strong diabetes data positions CagriSema for dual obesity + diabetes indications, like tirzepatide (Mounjaro/Zepbound)

Women Drinks to Reach 0.08% 100 lbs ~1.5 standard drinks 120 lbs ~2 standard drinks 140 lbs ~3 standard drinks 160 lbs ~34 standard drinks 180 lbs ~4 standard drinks 200 lbs ~45 standard drinks Men Drinks to Reach 0.08% 140 lbs ~3 standard drinks 160 lbs ~34 standard drinks 180 lbs ~4 standard drinks 200 lbs ~45 standard drinks 220 lbs ~5 standard drinks 240 lbs ~56 standard drinks All estimates based on Widmark Formula at approximately 1 hour elapsed time

Hormone imbalances and thyroid issues can interfere with metabolism, meaning shots alone wont address the root cause

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