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There isn't a universally agreed-upon answer, and frankly, the optimal protocol likely depends on the specific nature of the injury and the goals of the study

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Reference: Bjrn Pasternak, Viktor Wintzell, Anders Hviid, Bjrn Eliasson, et al

Halin S, Hammarsten P, Adamo H, Wikstrom P, Bergh A

Approximately half your bodys methylation efforts are used to create creatine, which muscles require to quickly produce energy (ATP)