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CYP2E1 oxidation generates reactive oxygen species (ROS) as byproducts

Posttranslational modifications of ROS-mediated kinase activity most probably contribute to the diversity and intensity of gene expression following microbial activation of innate immunity (Kolls, 2006)

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Specifically, an initial reduction followed by a substantial increase in beta-endorphin levels was observed, a pattern that suggests DSIPs impact on the opioidergic system, potentially playing a role in stress alleviation or adaptation processes