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Carnitine depletion can also result in intracellular accumulation of toxic acyl-CoA, resulting in impairment in several enzymatic processes (-ketoacid oxidation and gluconeogenesis, among others)

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This GLP-1 and GIP receptor agonist slows gastric emptying to improve glycaemic control, but this mechanism can also reduce bowel motility and increase water reabsorption in the colon, leading to harder stools

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Seizure 22 , 589600 (2013)

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