For conditions like rheumatoid arthritis, psoriasis, and psoriatic arthritis, methotrexate can: reduce inflammation and ease symptoms help prevent disease flare-ups slow disease progression and helps prevent joint damage (where applicable) improve daily functioning so you can do the things you enjoy reduce the need for corticosteroids help maintain disease remission
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Annals of the New York Academy of Sciences , 1271 , 3743
According to the Centers for Disease Control and Prevention (CDC) and NIDDK, you may be at higher risk for insulin resistance if you have one or more of the following: Excess body weight, especially around the abdomen A largely inactive lifestyle A family history of type 2 diabetes or prediabetes Age 35 or older (though it can affect younger adults and teens, too) Certain ethnic backgrounds, including African American, Hispanic/Latino, Asian American, American Indian, and Pacific Islander populations, which carry an elevated risk A history of gestational diabetes, PCOS, or sleep apnea Use of certain medications, such as glucocorticoids Keep in mind that risk factors are not a diagnosis