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Meanwhile, the Wegovy injection has two sets of results behind it: the STEP-1 trial found an average weight loss of around 17% over 68 weeks , while the newer STEP UP trial in 2025 looked at the higher 7.2mg dose and found an average weight loss of 21% over 72 weeks
However, small-molecule 3 was quite lipophilic (logD 7.4 = 5.7), resulting in high metabolic intrinsic clearance in human liver microsomes (HLM) (CL int = 130 mL/min/kg, Table S4), which would likely lead to a short pharmacokinetic half-life (t 1/2 ) and the requirement for an unacceptably high daily dose in humans
(2002) in the Journal of Clinical Endocrinology and Metabolism
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