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It includes some heartburn medicines including proton pump inhibitors (PPIs) such as esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole, H2 blockers such as famotidine and certain diabetes medicines such as metformin

When intake and interference are accounted for and the elevation persists, the result is interpreted by weighing hepatic, renal, hematologic, malignant, and functional possibilities

The majority of events were reported as diabetic retinopathy (4%, 2.7%, and 2.7%, respectively) and non-proliferative retinopathy (0.7%, 0%, and 0%, respectively)

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The goal is to choose the safest and most useful next step