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NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994

PMID: 40573323

4 Gut microbiota dysbiosis and abnormal activation of the innate immune system 4.1 Evidence for the association between complement components and schizophrenia Current studies have identified elevated transcript levels of complement components (C1qA, C3, C4, C5) in patients with schizophrenia (114) (see Table 2 ), suggesting, albeit not entirely consistently, that increased activation of the classical complement pathway may be associated with SZ

J Biol Chem 284:436445