Melanotan-2: The Shotgun Approach MT-2 hits the same MC1R receptor but also activates MC3R, MC4R, and MC5R : MC1R Melanin production (tanning) MC3R Energy homeostasis, cardiovascular function MC4R Sexual arousal, appetite regulation, erectile function MC5R Exocrine gland function, sebaceous secretion This non-selective binding is why MT-2 causes the "side effects" that many users actually seek out particularly the libido and appetite suppression effects
Following p53 knockout, SIRT7 expression decreases, resulting in elevated crotonylation at RRM2 lysine 283
6 (3) e50
The controlled attenuation parameter also decreased in ALT responders
Tirzepatide (MOUNJARO) Pronounced: tir ZEP a tide / mown JAHR OH Mnemonic: Tear zeppelin (over) Mount (Kiliman)jaro Year of release: 2022 Cost: $1060 / mo FDA-approved for: Type 2 diabetes Mechanism: dual GLP-1/GIP receptor agonist Available doses: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg (weekly subcutaneous injection) Dynamic interactions: Glucose lowering Kinetic interactions: Delayed gastric emptying, otherwise none significant in a bubble Tirzepatide (Mounjaro) is the first twincretin for type 2 diabetes