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Similarly, sex and race have not been shown to significantly affect drug clearance

The figure below captures this central tension: payers are almost evenly split in their perspectives on treatment of obesity, with some regarding pharmaceutical coverage for obesity as a response to a chronic medical condition, while others see it more as addressing a lifestyle issue

Morbidity and mortality weekly report

Furthermore, given the inherent biological variability across species, in practice the experimental data often do not allow a ready distinction between values of 0.67 and 0.75

Insulin resistance in noninsulin-dependent diabetes mellitus