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Two major clinical trials are the basis for most of what's known about these medications' weight-management effects: STEP 1 (68-week randomized study, adults without diabetes): semaglutide 2.4 mg produced an average loss of roughly 15% of body weight, versus about 2.4% with placebo, alongside a reduced-calorie diet and increased physical activity
PMID 25810047
How Cagrilintide Works in the Body To fully understand the Cagrilintide vs Retatrutide comparison, it helps to know how each one works on its own
(Figures 5C,D)
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