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doi: 10.1002/mnfr.202000426 51 AlshahraniFAljohaniN
GLP-1 and ghrelin mutually regulate the insulin system
A 6mg/mL concentration (30mg vial in 5.0mL) would require a 2mL injection for a 12mg dose, which is within the standard range for subcutaneous administration
However, Zierke et al., using a Rab7 knockout mouse modelRab7 being a key GTPase involved in lysosomevesicle fusionobserved that trypsinogen activation still occurred and pancreatic injury was not substantially delayed, even when lysosomezymogen granule fusion was disrupted
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