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We performed 13 C 2 -acetylcarnitine tracing and found that around 58% of cellular acetyl-CoA is derived from supplemented acetylcarnitine (Extended Data Fig
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The findings are impactful because they suggest that circadian alignment through TRE may restore -cell responsiveness and metabolic efficiency independent of medication. Mirmiras third pick, Genetic Risk and Transition Through Preclinical Stages of Type 1 Diabetes , from July, demonstrates that genetic risk continues to shape disease progression even after autoimmunity has begun in type 1 diabetes. Using a large TrialNet cohort, Andrea K
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