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In contrast to those in other tissues, the membrane of the barrier-type brain endothelial cell (BEC) is continuous and sealed by extra intercellular junctional structures, such as tight junction protein zonula occludens-1 (ZO-1), claudins-1, -3, -5, and -12, and occludin

Some research teams combine the MOTS-c 5-amino-1MQ stack with growth hormone secretagogues like ipamorelin or CJC-1295 to target both fat oxidation (MOTS-c, 5-amino-1MQ) and lean mass retention (GH secretagogues)