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Tirzepatide is a novel therapeutic agent that operates as a dual agonist, mimicking the action of two naturally occurring incretin hormones: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)

Optimizing the sequence and combination of these treatment modalities is the key to improving patient prognosis

For oral semaglutide 3 mg, 7 mg and 14 mg vs sitagliptin 100 mg, the estimated treatment differences (ETDs [95% CI]) were 2 (4, 1) mmol/mol, 8 (9, 6) mmol/mol and 11 (12, 9) mmol/mol, respectively

Semaglutide works on the single GLP-1 pathway with a long, well-documented history

TNF-, a transmembrane protein, preferentially activates TNFR2, which is generally associated with cell survival and immune regulation