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Tirzepatide has a shorter half-life of about five days, according to the Zepbound label

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If you begin to notice increased hunger, cravings, or dips in energy, it could mean your body is adapting to the medicationor that external factors like stress or sleep are interfering with your results

46 Drug-Drug Interactions: Saxagliptin is a strong CYP3A4 inhibitor, so its labeling recommends limiting saxagliptin to 2.5 mg daily in patients taking other strong CYP3A4 inhibitors, such as ketoconazole, based on the risk of increased saxagliptin levels