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This slow titration helps your body adjust and minimises side effects: 6 Weeks 1-4: 0.25 mg once weekly Weeks 5-8: 0.5 mg once weekly Weeks 9-12: 1.0 mg once weekly Weeks 13-16: 1.7 mg once weekly Week 17 onwards: 2.4 mg once weekly (maintenance dose) Practical tips for taking both medications Inject Wegovy on the same day each week, at any time of day, with or without food Continue taking metformin with meals as prescribed Stay well hydrated, especially if experiencing gastrointestinal side effects Eat smaller, more frequent meals if nausea is troublesome Limit ultra-processed food and take-aways Who should not combine Wegovy and metformin

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This multifaceted, integrated approach successfully protects against radiation-induced proctitis, expanding the application of polyphenolic drugs in preventing and treating radiation-induced injury

This article examines the scientific evidence, clarifies berberine's mechanisms, and provides guidance on its appropriate use within the context of UK clinical practice

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