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Yes restoring SCFA production, mucosal integrity, and microbial diversity helps maintain natural GLP-1 signaling without medication
However, the demarcation between asymptomatic hyperuricemia and gout remains clinically ambiguous as only approximately 50% of patients with prolonged hyperuricemia develop gout within 15 years (Xiang et al., 2024
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Participants with obesity (body mass index (BMI) 30 kg/m) and moderate-to-severe KOA pain experienced significantly greater reductions in body weight and OA-related pain with weekly semaglutide injections compared to placebo [52]
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