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The unusual phenomenon is a result of rapid weight loss, which may cause foot pain, changes in shoe size, and a more bony appearance in the feet
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However, if the purpose of the drug is to be taken up by the liver, then first-pass metabolism may be irrelevant (the drug is still metabolized into hepatic glutathione, which is what matters)
Plant Cell 12, 19391950
Well, first of all, I have a chapter in the book where I go through the history and as you point out, these drugs, the first one was approved over 20 years ago
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