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DSIP is therefore used in laboratory models to study circadian variation in pain sensitivity, central processing of nociceptive signals, and peptide-mediated modulation of neural pathways involved in pain perception

But its origins are the key to its primary function

If you're dealing with any combination of the following, SIBO should be on the list of things to rule out: Bloating that worsens throughout the day or after meals Chronic gas, cramping, or abdominal distension Alternating diarrhea and constipation Food intolerances that seem to multiply over time Nutrient deficiencies despite a decent diet Fatigue, brain fog, or skin issues that track with digestive flare-ups Previous food poisoning followed by ongoing digestive problems History of PPI use If you've already been diagnosed with IBS and treatments aren't working, testing for SIBO is a logical next step that many gastroenterologists skip

From there you can move into more advanced treatments as necessary

Infection of BSO-treated and untreated BMDMs resulted in similar amounts of IFN-I production in WT cells