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Used long term for decades (which bigpharma wants) without proper monitoring (e.g., DEXA scans), adequate nutrition, and resistance training, they amount to a large uncontrolled experiment

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They offer a shortcut to managing weight - instead of learning healthier ways of managing weight and appetite - which can be dangerous, especially for those who are vulnerable to having difficulties with body image and eating. There are risks, too, for those - like me - without a history of disordered eating