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Creatine in older adults Much of the creatine research relevant to semaglutide users comes from studies in older adults, a population that shares key similarities with GLP-1 users: they are prone to muscle loss, often have reduced protein intake, and benefit enormously from resistance training but may struggle with training intensity
Peptide Science Journal , 45(6), 674-687
The first-time AOM semaglutide prescribing rate was 0.1% in January 2024 and reached 0.2% by July 2024
The appetite suppression these drugs create makes it difficult to eat enough protein to preserve muscle mass, and roughly 25% of weight lost on GLP-1 drugs comes from lean tissue on average, with some trials reporting up to 40%
Additionally, any symptoms that interfere with the ability to fall asleep or stay asleep, leading to significant daytime fatigue or impaired concentration, require professional assessment
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