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Activation of these receptors in the brain (particularly brainstem and hypothalamic regions) suppresses appetite, reduces food intake through both homeostatic and hedonic pathways, slows gastric emptying to prolong fullness, and inhibits postprandial glucagon release to aid glucose control
This latter patient group is likely comprised of individuals on a standard omnivorous western diet and not on supplemental carnitine
The difference is even more pronounced for PfGrx C32S/C88S
No differences in response were observed between male and female adult worms for any of the compounds tested
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