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The antioxidant activity may be attributed to curcumin, the main polyphenol and active compound present in Curcuma longa which has the ability to increase the level of antioxidant enzymes, which include catalase, superoxide dismutase, and glutathione peroxidase (Panahi et al., 2012

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We have previously reported that GRK2 levels increase in several key metabolic tissues in experimental conditions promoting insulin resistance (IR) and that GRK2+/ mice (the use of GRK2/ animals is not experimentally possible since they die during embryogenesis [33]) are protected against high-fat diet (HFD)-induced obesity and IR

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