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When infused for 1 week, oIGF-1 increased organ growth of the heart, kidney, spleen, and adrenal glands and stimulated skeletal myoblast proliferation compared to SAL without increasing muscle fractional synthetic rate or hindlimb muscle mass
Longer breaks (8+ weeks) often warrant a gradual restart using a lower starting dose to minimize gastrointestinal side effects and allow your body to re-acclimate

Some patients experience nausea or early satiety when consuming rich foods, particularly during the dose titration phase
However, it is crucial to note that it should not be used in patients with a known allergy to cobalamin or cobalt

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