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This combination promotes the increase of GH by both increasing the strength of the GH release pulse and increasing the number of cells that secrete GH with the two pathways converging on the somatotroph to produce a supraphysiological GH response that neither compound achieves independently

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It works synergistically with growth hormone (GH) to enhance the breakdown of fats and promote ketogenesis

At the formulation level, developing novel drug delivery systems through structural optimization and nanotechnology represents a key priority, with glycyrrhizin-based nanocarriers already demonstrating improved oral bioavailability and hepatic targeting in preclinical studies (Li et al., 2026