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Endogenous causes (medical conditions) When B12 is elevated without supplementation , it can indicate that the body is releasing stored B12 from damaged tissues, producing excess B12-binding proteins, or failing to clear B12 normally

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For example, as explained in a 2024 review, people with premenstrual dysphoric disorder (PMDD) typically have normal female hormone levels throughout their menstrual cycle.16 With that being said, the breakdown below details some of the ways female hormone changes including imbalances and natural fluctuations can uniquely impact the health of AFAB individuals

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