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Weight loss in patients with obesity but no HF is associated with effects that would be expected to reduce symptom severity and improve exercise function in patients with HFpEF, including reversal of hypertrophic chamber remodeling, improvement in ventricular mechanics and reductions in hemodynamic congestion 13,14

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While there have been studies to show that people with MTHFR gene variants are more likely to have babies with neural tube defects, most of those studies were done in countries where there isnt routine folic acid fortification

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