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These can include triptans, which are commonly used for migraines, or preventive medications that are taken on a daily basis to reduce the frequency and severity of headaches

10.1016/j.eujim.2019.03.001 221 ParkJ.-H.KumY.-S.LeeT.-I.KimS.-J.LeeW.-R.KimB.-I.et al (2011)

All reported findings originate from structured laboratory or regulated human clinical research environments

We did not observe any change in spontaneous physical activity level and we found that calorie-matched group did not lose weight to the same extent as the Melanotan-treated animals, suggesting that the drug increases energy expenditure