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However, up to 40% of patients do not achieve satisfactory relief, prompting investigation of combination therapy, most commonly adding a second agent (e.g., duloxetine plus pregabalin), which can yield incremental pain reduction of 1020% but with increased risk of sedation, dizziness and drug interactions [64]
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The sensitivity of the response of human TT thyroid C cells to GLP-1 that resulted in producing cAMP and releasing calcitonin was different from the rat C cell lines MTC 623 and CA-77
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