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FDA approves the first oral GLP-1 medication January 4, 2025 Summary: The FDA approved the first oral GLP-1 for weight loss, a high dose of semaglutide, and a second oral GLP-1, orforglipron, will likely be approved soon

High glucose levels lead to the creation of advanced glycation end products (AGEs), which contribute to fibrotic tissue formation [28], and both AGEs and excess insulin can promote fibroblast proliferation and ECM production [29,30]

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The cryo-EM structure, resolved at approximately 3.0 angstroms, showed that orforglipron occupies a pocket within the TMD that is entirely distinct from the peptide-binding site

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