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The meta-analysis showed that GLP-1 agonists were associated with 1.23 odds of pulmonary aspiration (P= 0.59 and 95% CI of 0.58 to 2.60, not statistically significant)

It is believed that the drugs mechanism of action, which slows the rate at which food is released from the stomach, may cause this serious and painful condition

Furthermore, gene-editing therapies targeting Angiopoietin-like 3 (ANGPTL3) 399,400 and LDLR 401,402 have entered the preclinical stage, highlighting the broader potential of gene-editing-based lipid-lowering strategies, and long-acting therapies that provide stable and durable lipid-lowering effects could further reduce the risk of cardiovascular events

Treatment is time-limited and must be delivered as part of a specialist multidisciplinary programme

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