The concentration of cytokines and chemokines was quantified using the V-PLEX from Meso Scale Discovery (MSD)
Geroprotective and Anticarcinogenic Activity Lifetime Murine Studies Long-term studies in mice demonstrated that DSIP administration over a lifetime decreased total spontaneous tumour incidence 2.6-fold compared to untreated controls, slowed age-related switching-off of oestrous function, decreased the frequency of chromosome aberrations in bone marrow cells by 22.6%, and increased maximum lifespan by 24.1% compared to control groups a multi-parameter geroprotective profile that is among the most striking reported for any short regulatory peptide, and that has generated sustained interest in the DSIP analogue research field
Pearsons correlation coefficient was calculated to assess the strength of association between qRT-PCR and RNA-sequencing data
[Read More] Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA
The peptide, made from human gastric juice, is not approved for clinical use in any country (13)