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Zhong et al
Understanding these receptor shifts provides a specific target for future research: determining if local estrogen metabolism within the 3D niche can be modulated to arrest tissue growth
In the future, the integration of metabolomic readouts, single-cell and spatial transcriptomic localization, and metabolic modeling analysis is expected to establish a research framework of metabolic stratification-target selection-efficacy prediction, thereby reducing the risk of failed extrapolation across different diseases or populations (138)
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