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In clinical trials, Semaglutide GLP-1 has been studied for different durations, ranging from 16 to 68 weeks, with varying dosages
Pierre L, et al
The study shows they prevent new addictions by 14-25% (alcohol, opioids, cocaine, nicotine) AND reduce deaths by 50% in people with existing substance use disorders
The GLP-1 receptor agonists cardiovascular benefits are believed to stem from their effects in reducing dysfunctional body fat cells, improving glycemic control, reducing blood pressure and inflammation, and perhaps improving vascular endothelial function and plaque stability
Notably, exenatide has been shown to induce the overexpression of -endorphin and analgesia via an autocrine secretion of IL-10, instead of IL-4
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