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In patients with hepatic encephalopathy, the impaired reaction of cerebral oxyhemoglobin concentration might occur due to astrocyte swelling and dysfunction 42,43,44 because some reports showed that astrocyte controls the regional cerebral blood flow and provides energy sources such as ketone body and carnitine to the neuron 39,41

*Correspondence: Fabienne Micheli, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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