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Many patients report that after about 4 weeks of weekly injections, they observe improvements such as more steady energy levels and easier weight loss progress
PWS is a multisystemic disorder, and its clinical manifestations include developmental delay/intellectual disability, behavioral problems, dysmorphic facial features, short stature, scoliosis, and endocrine abnormalities such as hypogonadism, growth hormone deficiency, hypothyroidism, and central adrenal insufficiency
The reduction of the cob(II)alamin state to the cob(I)alamin state is required to allow methionine synthase to continue to convert homocysteine to methionine
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