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For example, in the hypoxic core of advanced solid tumors, a series of chain reactions caused by the high infiltration of immune cells enhanced the expression of the original gene, promoted tumor malignancy, and resulted in the emergence of drug resistance [76]

PMID 22761313

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Joint pain during GLP-1 treatment may result from rapid weight loss altering biomechanical loading on joints, increased physical activity levels, or pre-existing musculoskeletal conditions such as osteoarthritis, which are common in people with type 2 diabetes or obesity

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