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Side Effects Gastrointestinal symptoms: Most common adverse effects were mild-to-moderate nausea, vomiting, and diarrhea, occurring primarily during dose escalation [6] [12]
According to the trial protocols, the general rule was that if a dose was missed, it could still be administered within a defined window, usually several days after the scheduled date, without disrupting the escalation plan
Therefore, initial studies could be designed to explore whether and how GLP-1R agonists alter GABAergic and dopaminergic pathways in the brain
Research has demonstrated that: Oral semaglutide is as effective as injectable semaglutide in achieving these outcomes
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