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4a).The co-therapy decreased food intake with comparable efficacy in WT and Per-Gipr KO mice, but with significance of the co-therapy over acyl-GLP-1 reached only in the WT mice (Fig
Clinical trial data show that gastrointestinal adverse effectsincluding nausea, vomiting, diarrhea, and abdominal discomfortoccur in 20-50% of patients initiating GLP-1 therapy, with rates varying by specific agent and dose
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