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Side effects are relatively common but generally manageable

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This cycle of alternating diarrhea and constipation can be tough on the digestive system and worsen hemorrhoid symptoms

However, because FAERS does not account for total prescription volume, these differences should be interpreted cautiously and not as definitive risk comparisons

Schlessinger points out that many patients in these studies already had advanced disease before starting treatment, which makes it difficult to pin new changes directly on the medication