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Higher NAD+ activates the sirtuin family of NAD+-dependent deacetylases, particularly SIRT1, which deacetylates PGC-1alpha (promoting mitochondrial biogenesis), FOXO transcription factors (enhancing stress resistance), and NF-kappaB (reducing inflammation)
This combination supports methylation, a critical biochemical process that has a significant impact on the bodys ability to regulate its cardiovascular, neurological, reproductive, and detoxification systems