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The systemic distribution of the molecule is rapid

[82] As a glucagon-like peptide-1 receptor agonist, semaglutide suppresses the release of glucagon by the liver which in turn lowers blood pressure

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In contrast, SGLT2 inhibitors and GLP-1 receptor agonists are newer standard therapies that reduce glycemia while conferring proven cardiovascular and renal benefits, making them preferred agents for improving outcomes beyond HbA1c reduction alone