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However, GSH levels were not completely abolished, which may be due to the presence of GCLC-expressing cells in the tumour microenvironment (Extended Data Fig
[4] Wilding JP
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While the ipsilateral precursory lesion could be explained by an early focal invasion by immune cells that remain dormant for years, the contralateral mirror lesions are harder to ascribe to such a mechanism
Adoptive cell therapy (ACT) using activated CD8 + T cells with genetic deletion of GPX4 also failed to enable antitumor immunity and subsequent tumor control
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