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Alternatives to Semaglutide for weight management include medications such as: Orlistat Phentermine-topiramate Naltrexone-bupropion Liraglutide In addition to their use in chronic weight management, some of these medications, like liraglutide, also serve as alternatives for managing blood sugar levels and high blood pressure

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While metformin demonstrates effective cardioprotective benefits in diabetic patients, its therapeutic effects in non-diabetic individuals remain mechanistically unexplained

GLP-1 secretion in patients with type 2 diabetes GLP-1 hypersecretion was described in some early studies [18, 49] in response to the ingestion of oral glucose, probably related to the use of side-viewing antibodies, which also detect the major proglucagon fragment [50]