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10.1002/jcp.22950 J

Intra-colonic propionate increases plasma gut hormone levels via an FFA2-dependent mechanism in mice To determine whether the reduced PYY and GLP-1 secretory responses to propionate observed in primary colonic cultures from FFA2 / mice in vitro translated into impaired gut hormone secretion from these mice in vivo , portal vein plasma PYY and GLP-1 responses to a single intra-colonic injection of propionic acid (180 mmol l 1 ) or saline control were investigated in FFA2 / mice compared with their WT littermates

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